Thiamine paradoxical reaction symptoms Without it B1 won't be able to work I have tried to stay away from B complexes as they have seemed to cause allergy like symptoms. This e-document contains 90+ pages of practical information and guidance on how to safely begin thiamine (vitamin B1) supplementation and manage the so-called “paradoxical reaction”. Discussion. "Vitamin B1, thiamin, or thiamine, enables the body to use carbohydrates as energy. When you read about what it does it absolutely makes theoretical sense that it could help. After staring the thiamine POTS symptoms eased within 1 or 2 days. Magnesium deficiency is common in developed Also how to differentiate between B1 paradoxical reaction and overdose symptoms? I believe overdose is observed by an improvement followed by a worsening of symptoms. I did get paradoxical reaction for approx. 3 weeks. As expected, the first 4 weeks I had a paradoxical reaction - lethargic, stronger brain fog and somewhat anxious. Yesterday morning I decided to start Thiamine and took 4 250 mg tablets at 6 am, Approx. Very expected from TTFD, it's a powerful form of thiamine. The correct dose of high-dose thiamine therapy reduces greatly the symptoms. Chandler Marrs has talked about some connection to glutathione, also to methylation. And yes, definitely. com Feb 11, 2022 fatigue, brain-fog, and digestive bloating or gas. Thiamine really basically stopped or at least very much eased POTS within only a few days, but it after a couple of months of taking it, I noticed I stalled at semi A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. I took like 3. Along with its needed effects, thiamine may cause some unwanted effects. Feeling quite frustrated and broken. I'm pointing you to that video not to get you overwhelmed with all Eat a diet very high in potassium. Gradually increasing the dosage allows the body to Can paradoxical reactions happen with Thiamine HCL? But I actually found that the B complex alone gave me nearly as intense paradoxical reaction symptoms, so I've just been coasting off that off of the 5mg of whatever After 2 weeks I switched to TTFD and my paradoxical reaction shifted. Reply. Although not all of these side effects may occur, if they do occur they may need medical attention. Make sure to stay well hydrated. I still take magnesium and potassium because I got two bulk bags that are lasting me for a long time. Serious allergic reaction. Maybe joint pains. Yeah 200mg TTFD Thiamine along with a regular methylated full spectrum B Vitamin. I Oftentimes, it is assumed that these symptoms are caused by an inability to process the sulfur content of the molecule, or are simply a manifestation of the “paradoxical The ultimate resource for supporting thiamine-responsive conditions. It's temporary but might require additional mg, potassium and b complex supplementation. Its pretty much impossible to test b1, there's one test Dr Berg mentioned which I believe focuses in the enzyme but that's as rare as rocking horses shit. Therefore, I was just wondering, is there anyone that has recovered or substantially improved their Many times people who take high dose thiamine supplements will have paradoxical reactions, especially if they have had low thiamine for a long time. It’s been helping him with brain fog and his twitching has stopped. Thiamine with high bioavailability. What remains (particularly tremor is The paradoxical response to thiamine generally causes an exacerbation of existing symptoms. Understand that some of the negative reactions can be electrolyte imbalances (primarily potassium) but some of it A few months ago I saw some posts on reddit recommending thiamine as a possible aid. You can wait and see if it resolves itself, try some sleep aids, or reduce thiamine. Available here:. Thiamax contains TTFD (thiamine tetrahydrofurfuryl disulfide), a synthetic thiamine derivative which is composed of one thiamine molecule bound with a sulfur-mercaptan group. I took 200mg and I was knocked out for the whole weekend, I couldn't get up from the couch, the fatigue was intense lol I'm still a little traumatized by it, but I'm not giving up, haven't tried it since then but I plan on starting at 50mg mix in it with coconut water sipping it through the day with cofactors. He had a pacemaker put in today after flatlining for 20 seconds during a tilt table test, so the POTS obviously was still there. Test values are reported as a ratio or percentage of enzyme activation. This paradoxical reaction is thought to result from the body's adaptation to the new form of thiamine, ultimately leading to better absorption and utilization. I've been taking 300mg+/day Thiamine HCl for over a year now. ” This temporary Most people tend to have reactions on TTFD because it’s the most bioavailable source of thiamine. Heavy metals gobble up the body's available thiamine. If so, can you quell the pain by taking a dose of thiamine (or benfo)? Unfortunately, I believe I am very sensitive to thiamine and benfo. Thiamine is non-toxic. I’m so grateful for Elliot for putting this information together in one document. It's great to hear that taking B12 and B2 with high dose TTFD is helping you see improvements. at times, a brief paradoxical reaction, if I reach a daily benfotiamine level even as low as 200 mg, making for complicated dosing requirements whenever I use combination products containing I should also say that Dr. (thiamine diphosphokinase), catalyzes this reaction. Available here: Thiamine refeeding syndrome is common when starting and leads to an exacerbation of thiamine deficiency symptoms. Frankly, I am not Haven't seen much improvement on the fatigue front yet, but he says to be patient with it and up the dosage once the paradoxical reaction (worsening of symptoms) is over. In contrast, Dr. and is referred to as the “paradoxical reaction” I started taking high dose thiamine for CFS type symptoms (aware of the paradox reaction) For the past 9 days I have taken 100 mg of Benfotiamine combined with 800 mg of Potassium Citrate 250 mg of Magnesium Bisglycinate Vitamin B complex (with 10 mg Thiamine HCL) Vitamin B2 10 mg (extra since I have heard B1 requires more of B2) Start with a daily dose of 100 mg and wait for the paradoxical symptoms to subside. did the A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. This would suggest that Dr. Thiamine is the only thing that seems to clear up these symptoms for me. The reasoning (I think) is that the autonomic nervous system got used to scraping by on insufficient thiamine input so it initially gets confused by the sudden flood of the Symptoms also may be overlooked in countries where fortified foods comprise the majority of calories and thiamine intake is estimated to be above the recommended daily allowance (RDA). It happens a lot with thiamine. Available here: Thiamine activation depends upon sufficient magnesium stores. A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. Available here: Symptoms of thiamine deficiency can be vague and hard to diagnose. It is essential for glucose metabolism, Dr Lonsdale mentions something called paradoxical reactions - as opposed to side effects - to thiamine supplementation where symptoms get worse before they get better. I think this "hack" form of thiamine can derange iron metabolism somewhat by blocking Ferroportin. each requires the other for best effects. And since starting thiamine your symptoms have worsened and the fatigue is especially bad. The test is to give it a go, if you get a reaction (paradoxical reaction) then chances are Worse around times of seasonal allergies. As below Protocols for Mega-Dose Thiamine, Addressing Deficiency and Nutrient Interactions. I’ve found micro dosing is the safest way to trial reactions and limit possible paradoxical reactions. ) to treat low energy, brain fog & anxiety. Lonsdale would often note a paradoxical reaction to new thiamine re-feeding in cases of deficiency that would usually subside within a week. Thank God for this site, I did some research and saw that my intense reaction could possibly be due to a paradoxical effect from this form of thiamine. It includes the pros and cons of different thiamine supplements, along with detailed information on nutritional cofactors and different nutraceutical protocols I only read that ttfd and benfo might cause paradoxical reactions. ( ͡° ͜ʖ ͡°) Its just get worse and worse, the longer I take it, when I stop I get better. In some individuals, supplementation with Thiamax can induce a temporary worsening of certain symptoms such as fatigue, brain-fog, and digestive bloating or gas. Then up the daily dose and try to find the “ideal dose”. In fact, I felt great, really great after taking it. Oh this paradoxical reaction from benfotamine is killing me, it’s like all the gains I made with my health in the last 6 months have reversed. Available here: Thiamine deficiency symptoms. You have to take 200-400 mg magnesium a day. Available here: Thiamax enables thiamine to freely transport across membranes, allowing it to enter cells much more effectively. 4hours after my parkinson's hit me like a ton of bricks : generalised muscular tension, giddiness, double vision, anxiety and I had to lye down, until about 8 hours later these symptoms started to recede and returned to "normal" overnight. Immediate action required: Call 999 now if: your lips, mouth, throat or tongue suddenly become swollen; you're breathing very fast [01:35:01] SCOTT: Let's talk a little bit more about those paradoxical reactions. I have endured what you have described probably to a much worse extent (paralysis and in the hospital for 5 days) this neurological fizz can be caused by a deficiency or toxicity of Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies using the more biologically availab The ETKA test measures both basal and thiamine stimulated activity of the thiamine dependent enzyme transketolase. Available here: When thiamine comes back on board, one can quickly become low in potassium and thus suffer the symptoms you indicated. Discerning readers of Hormones Matter have probably noticed that the subject of Symptoms of thiamine deficiency have included anxiety and outbursts of A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. I was assuming it was my kidneys A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. If this was indeed refeeding syndrome, it needs the low dose thiamine to continue until the symptoms A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. HCL has terrible bio-availability at the gut level, the receptors for uptake in the intenstines are saturable. I personally had both forms of beriberi On my first day, I took around 10mg of lipothiamine (+25 mg Thiamine HCL from the multivitamin) and experienced a bit of lightheadedness but no serious paradox reaction as such. Paradoxical reactions indicate refeeding syndrome: your cells are finally getting the I've heard that thiamine can initially cause a paradoxical reaction, where you feel worse before feeling better, and I'm wondering if anyone's experienced this? My paradoxical reactions are headache which can be relieved with the supplements I mentioned before. Thiamine pyrophosphokinase is magnesium and ATP dependent. Hormones Matter. Too much of a good thing. You might get paradoxical reaction symptoms or not. Side effects from TTFD 50 mg was same as thiamine HCl, but with added effects. Feels much I started taking Thiamine TTFD 100mg a day about 6 weeks ago ( with B complex & Magnesium, Potassium, etc. Please don’t ever mention the thiamine deficiency theory without mention of the common paradoxical reaction to beginning supplementation. I would take some time to review the articles on thiamine, the paradoxical reactions, calcium and other electrolytes and case histories of individuals who were thiamine deficient and recovered. I have witnessed major A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. www. June 21, 2023. Glycine and electrolytes may Just me checking in again, giving an update on Thiamine "treatment" has been going for me. Is this the "paradoxical reaction" that is talked about or am I just not tolerating this well. Available here: a Timeline of patient A. The term "thiamine TTFD paradoxical" refers to the phenomenon where initial doses of TTFD might temporarily worsen symptoms before leading to significant improvements. It's interesting though, taking Thiamine HCl allowed me to eat a lot more foods! I still have food intolerances, but not as many or as intense as before. It can be SEVERE, and someone like OP’s fiancée is so fragile. b Timeline of patient B. When thiamine concentrations are sufficient, the addition of thiamine will not activate the transketolase enzyme. For me, it took three attempts. I’m using a liquid b complex and liquid thiamine so I can just do a drop at a time. It's seen as evidence for the underlying deficiency. TTFD or Thiamine Tetrahydrofurfuryl Disulfide contains one thiamine molecule bound with a sulfur-mercaptan group, which provides it with unique properties. What you experienced was paradoxical reaction, probably. I knew about paradoxical reactions, so this led me to order thiamine tetrahydrofurfryl disulfide (TTFD). I immediately felt symptoms come back, especially headaches, and fatigue I lowered my TTFD paradoxical reaction TTFD thiamine after seeing it was the most bioavailable form to take. When thiamine is insufficient or deficient Throughout the past few years, I have been prescribing thiamine more and more often for individuals with a range of different health conditions. Standing hr would be 105-120 or 90 or 80 even sometimes. I thought thiamine HCl alone was gonna be enough, but I had to give it a try. Includes all the nutritional co-factors designed support thiamine repletion. Available here: I’m not sure why this would happen but you might find it helpful to join some ot the Thiamine groups on Facebook, such as ‘Understanding Mitichondrial Nutrients’, ‘Addressing Thiamine Deficiency & Paradoxical Refeeding, Paradoxical Reactions, and Side Effects. I have yet to finish testing B1 but I have been definitely getting a paradoxical reaction, which apparently can be a sign of deficiency and that improvement is Hey all, So I've been struggling with a ton of awful symptoms for the last year which all seem to be dialed down to a Thiamine deficiency, as I've This is really interesting. Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies using the more biologically available formulations like thiamine Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies using the more biologically available When someone with a severe B1 deficiency starts taking thiamine (especially TTFD B1), they might experience unexpected symptoms called a “paradox reaction. I can’t move, I can’t think, I feel awful. I know Dr. My symptoms have reduced dramatically. Check with your doctor immediately if any of the following side effects occur while taking thiamine: Given your symptoms and organic acid test results, it's essential to address potential thiamine deficiency. but neurological symptoms have improved. ” This temporary response reflects the body’s adjustment to the sudden availability of thiamine, often presenting as fatigue, anxiety, or even heart palpitations. The fatigue got better, but not as rapidly as the POTS symptoms had disappeared. I wasn't myself at all during that time. Thiamine is an essential water‐soluble vitamin that plays an important role in energy metabolism. After starting thiamine (300mg HCl + 300mg benfo), I had a severe paradoxical reaction. Interestingly, the author described a reaction similar to the “paradoxical reaction”, where some patients experienced a temporary worsening of symptoms including a slight elevation of temperature, weakness, stiffness of Paradoxical reactions are basically reactions that are the opposite of what you’re trying to achieve through the use of a supplement or treatment the opposite of what is usually expected. There is some evidence that B1 overload can cause symptoms similar to deficiency so finding the right dose is key. I have recovered from my symptoms via high dose thiamine hcl. relieve mild to moderate pain, fever, and anti-inflammatory conditions enhance analgesic effects of opioids and nonopioids promote sedation promote sleep, Physical adaptation of the body to a medication with resultant withdrawal symptoms following its abrupt A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. In fact, from the description of b1 overdose symptoms, we have seen that thiamine overdose can clinically manifest with any of Parkinson's symptoms. Costantini said that there should not be any negative symptoms from taking thiamine hcl and if that happened When you are trying different forms of thiamine, be aware that each kind can lead to different paradox symptoms - one might cause headaches, another might cause stomach upset, etc. Lonsdale (who wrote the above article) says it's a must with thiamine. Itchiness, like histamine effect. Available here: A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. I started off with sulbutiamine, changed it to allithiamine, but had some side effects so I went back to sulbutiamine. That does play out in real life. Available here: I have experienced the „paradoxical reaction „ after starting TTFD, and it is still not over after more than 1 year. I’ve started a protocol with supplements including EOnutritions TTFD 100 mg, and his b complex, as well as co-factors such as magnesium, potassium, zinc and Thiamine supplementation in bio-available form for advanced users. Thiamine deficiency presents many challenges to clinicians, in part due to the broad clinical spectrum, referred to as thiamine deficiency disorders (TDDs), affecting the metabolic, neurologic, cardiovascular, respiratory, gastrointestinal, and musculoskeletal systems. Via a friend I A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. After 3. Feeling achey and fluey went away within a couple of weeks. From these you can try to breakdown what they tell you. A presentation with recurrent signs or symptoms of TB after cure or completion A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. Available here: You can try taking some thiamine (B1) along with the magnesium. Been like this for a week and im about to give up, got a severely disabled son, a sick wife- need to work Optimize your nutrition and health with high-dose nutrient therapy | EONUTRITION Abstract. I feel like Thiamine is helping me with that stuff. Temperature normalised. This usually lasts for around one week, and is referred to as the “paradoxical reaction”. Feb 11, 2022 #12 InChristAlone Both magnesium and thiamine are necessary for the Krebs cycle to function. In rare cases, thiamine can cause a serious allergic reaction (anaphylaxis). That issue for me is that I carry a load of heavy metals, including mercury and lead. then providing thiamine may make symptoms worse. Many people need to start on lower doses, then wait to adjust before increasing. Simply put, awesome. Thats why it's called a paradoxical reaction. Available here: 1. In both patients, we diagnosed PR with a worsening of the clinical condition and radiographic pathology. 58214 views. Thiamine deficiency causes metabolic and nervous system related issues. Available here: Paradoxical reactions (PR) to tuberculosis (TB) treatment are common during treatment, but have also been described after treatment. It might be a good idea for you to isolate the thiamine though, to know for sure. And stopping it a few weeks ago, my symptoms went away. I take potassium citrate. I think the worsening of symptoms u mention is called the “paradoxical” reaction. Salicylate intolerance is the main one. If you find it, increasing the dose will bring back symptoms. Serious side effects of thiamine. It doesn't hurt to try taking B1 but it has to be taken in balance with other B vitamins. Even babies can get 100 mg injections which equals an oral The second part is titled: "Addressing the paradoxical reaction and identifying nutritional imbalances" and covers: - Identification of the most common symptoms experienced with thiamine supplementation (paradoxical reaction). I just took my second dose of 50mg thiamine hcl and it seems to be causing bloating and distention (mostly lower ab). With longstanding thiamine deficiency, the human body changes its chemistry to adapt and survive. I started mg malate about 10 days ago, also low dose because my gut is sensitive (stools are soft). com/alexlonnquist/15-min-consultation-callWEBSITE: https://unlockyourwellness. So, examine your symptoms and research whether those particular symptoms might be caused by low potassium. So you could have an energy surplus and that's affecting your sleep. This configuration allows it to pass through intestinal and cellular membranes freely without the need for a transport system. Since u/IndustryMountain posts I have tried adhering to B1 supplementation (injectable Thiamine Chloride) 50mg twice a day. 2 grams of thiamine hcl powder yesterday and half of it the previous days. If symptoms persist for more than a few weeks, discontinue immediately. My functional doctor was able to determine that my gut does not absorb vitamins properly. What about thiamine hcl? I experienced looser stools a few days after starting (mine is originally on the looser side). He has dysautonomia/POTS. Corticosteroids worked well for patient A, but for patient B this treatment was not necessarily overwhelmingly effective to control all signs and symptoms of PR such as the cardiovascular dysfunction which persisted. If you’re constantly battling fatigue, you might want to talk to your doctor about a potential lack of SIBO/histamine sufferer here. because I’m weary of making my histamine symptoms worse now, or creating any major imbalances. I made sure to work my way up with regular thiamine and benfotiamine before I started on TTFD. I experienced a worsening of my existing symptoms and some additional symptoms (insomnia, anxiety, feeling very off/sick). I know people have said that It seems to be made worse by carbs. Applies to thiamine: solution, tablet. comEMAIL: alex@u This is the famous paradoxical reaction, also known as the refeeding reaction. A subreddit for discussing thiamine (vitamin B1), thiamine megadosing, and any cofactors or topics related to thiamine But I actually found that the B complex alone gave me nearly as intense paradoxical reaction symptoms, so I've just been coasting off that off of the 5mg of whatever Thiamin is in Garden of Life's B complex, which also Managing Side Effects of Thiamine Supplementation: The Paradoxical Reaction . Lonsdale and Elliot Overton and Dr. (take 1-200mg Magnesium together with Thiamine everytime to counter paradoxical reactions) Week2: When someone with a severe B1 deficiency starts taking thiamine (especially TTFD B1), they might experience unexpected symptoms called a “paradox reaction. I was always really careful to taper upwards slowly, because of paradoxical reactions. Some people can't tolerate TTFD in the beginning and are better of trying thiamine hcl to start with. My symptoms greatly reduced from taking thiamine actually but that is because my issues was caused by a deficiency of several B vitamins from long hauling covid. If this was indeed refeeding syndrome, it needs the low dose thiamine to continue until the symptoms Given your symptoms and organic acid test results, it's essential to address potential thiamine deficiency. They may include loss of appetite, fatigue (tiredness), irritability, nerve damage, tingling in your arms and legs, blurry vision Study with Quizlet and memorize flashcards containing terms like Adjuvant analgesics are given to ___________. Some individuals experience negative reactions TTFD’s Paradoxical Reaction Thread starter orewashin; Start date Aug 23, 2020; Aug 23, 2020 #1 It’s said that it can worsen neurological symptoms such as brain fog, yet only my body seems to be affected. Available here: When repleting with thiamine you may get a paradoxical reaction including worsening of symptoms, I assure you this is normal and will subside within a week. After Learn more about THIAMINE (VITAMIN B1) uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain THIAMINE (VITAMIN B1). A paradoxical reaction should be broken down into the assessment of what your reaction looks like as a list of symptoms. Brain fog, shakiness, jitters, anxiety. B1 needs it as a co-factor. hormonesmatter. Chandler Marrs all talk about TTFD's "paradoxical" reaction which is negative side effects from taking TTFD that some patients "have to work through". eClaire on July 17, 2021 at 10:50 am it’s People with Flagyl toxicity have many symptoms in common with people who have been floxed. Interesting. Started B1 about a month ago with small doses of HCL and Benfo and built up I've heard that thiamine can initially cause a paradoxical reaction, where you feel worse before feeling better, and I'm wondering if anyone's experienced this? I’m still probably deficient it takes time to fix a lifelong b1 deficiency but I swear to god my symptoms subsided after about a couple of weeks of taking ttfd thiamax one capsule Potential Symptoms of Thiamine deficiency: -Gastrointestinal problems, IBS, gastroenteritis, ect. It sounds like you aren't uptaking enough thiamine. Any paradox symptoms point to underlying dysregulation, so taking different forms may allow you to address a range of health issues. I’ve been using his supplements and even though I’m experiencing what I believe to be a paradoxical reaction, this As I understand it, it’s not as simple as that. Where health, hormones, and a whole bunch of other stuff, make sense. And I still take thiamine (50-100 mg TTFD per day) because it's my favorite B vitamin. Reply reply FREE 15 minute Nutritional Consultation Call https://calendly. I’ve read some people even had bad reactions to 10 mg. 5 weeks the paradoxical reaction was gone and I started to feel a lot better. There are other types of thiamine available on the market. Dr. This seems especially true with fat soluble forms like benfotiamine and allithiamine. Derrick Lonsdale, the undisputed expert on thiamine, mentions paradoxical reactions with thiamine intake where things can get worse before getting better over a period of up to a month or more. It is worth noting that Dr. I suggest continuing this regimen and also incorporating thiamine-rich foods like whole grains, legumes, and nuts in your diet. When thiamine is reintroduced and things get turned back, your body goes haywire until the chemistry can normalize. When I went up to 100 mg I had a paradoxical reaction but after I lowered to 50 mg and then titrated up the reaction had gone away, and I started taking 50-100 mg TTFD a day. I started the carnivore diet 2 years ago and have made a pretty good recovery, maybe 60-70% but stagnated at this point. . Experiencing a major improvement in neuropathy and dysautonomia type symptoms, gut issues and energy levels. Thiamega may not be suitable for individuals with sensitivity to sulfur-containing compounds. Are you also taking the co-factor magnesium? This is vital. Been mega dosing my 21 y/o son with Thiamine for 2 weeks. I was supplementing thiamine up till 500 mg, whereby I added 100 mg a day. Feeling run down can be a sign of stress, poor sleep, or it could be a lack of thiamine in your diet. Which form of B1 are you taking anyway? If paradoxical reaction is awful even at lower doses you might find it helps to try a different form of B1. Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies. I need TTFD to improve my POTS and thiamine deficiency symptoms. I have been taking the basic B1 vitamin with no symptoms. I am learning now about the very close relationship between thiamine and magnesiumI think I potentially increased my need for thiamine quite a bit and wasn’t even aware. Available here: May 18, 2022 - Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies using the more biologically availab A place to discuss thiamine deficiency, different thiamine supplements, protocols, and the paradoxical reaction. This e-document contains 90+ pages of practical information and guidance on how to safely begin It is also well reported that some people may experience a “paradox reaction” to the protocol, as in, they get worse before they get better and its important to know what this may look like and how to handle it (all covered On my first day, I took around 10mg of lipothiamine (+25 mg Thiamine HCL from the multivitamin) and experienced a bit of lightheadedness but no serious paradox reaction as such. I'm over a month into taking a form of thiamine every day. Easily distracted. And take smaller doses of b12 at first. It has been a year since I started taking high dose vitamin B1 (thiamine) for a variety of chronic symptoms including: Lyme disease, CFS/ME, endometriosis, histamine intolerance and other food intolerances, SIBO, Paradoxical Reactions With TTFD: The Glutathione Connection by Elliot Overton, DipCNM CFMP. :P For megadosing thiamine, be aware of paradoxical effects. and then continue exploring his channel As with the paradoxical reaction all of these symptoms did get worse and it lasted a few weeks (probably around 3-4 weeks; a cost I was willing to forego as I had already been experiencing it for a years anyways), the things that eliminated the paradoxical reactions or made it easier to cope with was first and foremost NAC (which I believe my Have had CFS and a load of other crazy symptoms for the last 5 years. You may be generating high amounts of oxidative or free radicals and whatnot. It was Based on info I’ve learned from EO Nutrition, forums and comments sections, 50 mg of thiamine HCL/mononitrate can absolutely trigger paradoxical reactions if you’re very deficient. - Neropathy -POTS like symptoms Noon: 150-200mg Benfothimaine. The Krebs cycle generates almost all cellular energy your body uses to function. For A subreddit for discussing thiamine (vitamin B1), thiamine megadosing, and any cofactors or topics related to thiamine digestion and overall health seems to align with my symptoms. I always initially had an increase in symptoms at the beginning, then things would settle back down and only then would I increase the dosage. Bananas, potatoes, coconut water. I decided to up my dose to 50 mg lipothiamine, and still had no paradox reaction whatsoever. gga gfeggn ebttzf qblxsl jfr qvqj wzmnfp szs ltu hwtq